Sogang News

Highlights table
Title Prof. Lee Jung-chul Develops a World-First Micro Device For Analyzing the Mass of Protein Mixture
Writer sogpr Date 2017-07-31 Views 82

- Expected to be further advanced as a minimized tool for earlier diagnosis

without decreased performance -

 

A research team led by Prof. Lee Jung-chul of the Mechanical Engineering department at Sogang University has developed a micro-device for analyzing the mass of protein mixture based on the difference in flow time, representing a global first via joint research work with Prof. Thomas Thundat of the Chemical and Materials Engineering department at the University of Alberta, Canada. In other words, the team developed a micro-device available for the analysis of the mass of protein mixture and verified its effectiveness. The research result was posted on June 14 in Scientific Reports, an affiliated journal of Nature.

Prof. Lee Jung-chul said, "This time, we developed a technology that makes it possible to minimize the analyzing device, which has conventionally been very large, and to develop a portable analyzer that can easily be used outside.” He added, "Going beyond the fields of analysis chemistry, it is expected that the device will be further advanced to be utilized in the bio and medical fields as an early diagnosis tool."

From this Sogang-Alberta joint research project, the technique for analyzing the mass spectrum in the method of time-of-flow* on the mixed protein—by combining the technique for capillary tube* and electrophoresis* separation, along with the technique for precise mass measurement based on the U-shaped Hollow nanomechanical resonator (HNR)—was developed for the first time in the world.

 

* capillary tube: a small tube or pipe for which the internal and external diameters are small

* electrophoresis: electro-chemical phenomenon where the charge in the liquid moves toward the electrode of the opposite charge

* time-of-flow: time-of-flow refers to the time for passing the defined channel of flow, from the entrance to the exit of the capillary tube; the time differs based on the charge to the molecular weight of protein

 

[Figure] a. picture of Hollow nanomechanical resonator (HNR), b. mimetic diagram for experimental device, c. HNR's amplitude spectrum before injecting a sample, d. schematic diagram for flow conditions and velocity inside HNR and capillary tube

EMB0000242c5a65